More info at SynthSysEd website A highly motivated and talented Postdoctoral Research Associate is invited to join the laboratories of Dr. Abdenour Soufi and Prof. Susan Rosser at the University of Edinburgh to develop novel synthetic Biology tools for Cellular reprogramming applications. This is part of SynthSys Mammalian, which is a BBSRC/EPSRC/MRC Synthetic Biology Research Centre (SBRC), hosted by the School of Biological Sciences at the University of Edinburgh.
We are particularly interested in the interaction between transcription factors and chromatin during the conversion of human fibroblasts to induced pluripotent stem cells (iPSCs) (Soufi et al; Cell 2015, Soufi et al; Cell 2012). This collaborative project will focus on engineering synthetic transcription factors and will employ a wide range of techniques including; synthetic DNA-assembly and high-throughput-cloning, engineering synthetic transcription factors such as TALEs and ZFGs, human stem cell culture and lentivirus production, Next Generation Sequencing based techniques such as ChIP-seq, recombinant protein purification, DNA-protein interaction analysis such as EMSA and DNase-footprinting.
The successful candidate requires a PhD (or soon to be awarded) in an appropriate discipline with clear evidence of independent research capabilities. Knowledge and past experience in synthetic transcription factors, cellular reprogramming, stem cells and epigenetics are highly desirable.
The post is full-time for a fixed term of 3 years.