Jobs

[Closes 30 May 2018] Co-ordinator for Synthetic Biology Centre

We're looking to hire a Cambridge-based coordinator for the OpenPlant SynBio Research Centre and the Cambridge SynBio Strategic Research Initiative. Application deadline is 30 May 2018.

Full details of the post can be found at http://www.jobs.cam.ac.uk/job/17351/


The role-holder would work 50% to support the OpenPlant Synthetic Biology Research Centre and 50% with the Synthetic Biology Strategic Research Initiative (SynBio SRI). The purpose of the role is to help develop and implement a strategy that will enable both initiatives to become known leaders in the field and sustainable in the longer term.

OpenPlant (http://openplant.org) is a consortium funded by BBSRC and EPSRC comprising 20 labs spanning the University of Cambridge, John Innes Centre and the Earlham Institute (Norwich). The work of the Research Centre is intended to promote novel research on tools and applied traits for plant synthetic biology, open sharing of foundational technologies, and responsible innovation. The role-holder will work with the OpenPlant Directors and Management Group, including the OpenPlant Project Manager based in Norwich, to co-ordinate a variety of activities within the Research Centre.

The SynBio SRI (http://synbio.cam.ac.uk) aims to catalyse interdisciplinary exchange between engineering, physics, biology and social sciences to advance Synthetic Biology at the University of Cambridge. The role-holder will work with the SRI Co-Chairs and Steering Committee to develop, plan and deliver the SRI's vision and strategy. They will facilitate efforts to promote development of open technologies, build shared resources, and provide a hub for networking and discussion.

Responsibilities will also include co-ordinating seed funding competitions such as the Biomaker Challenge and OpenPlant Fund; organising formal and informal scientific meetings and forums; developing and managing relationships with stakeholders within and external to the University; seeking small and large-scale funding for future activities. The role-holder is additionally responsible for ensuring that synthetic biology activities in Cambridge are actively communicated and promoted, and is supported by the part-time SynBio SRI Events and Communication Co-ordinator.

The successful candidate will have a PhD in a relevant field and knowledge of Synthetic Biology research, policy and practice. They will have the ability to foster relationships with and between academics at all levels in an interdisciplinary context, and build partnerships with companies, funders and policy makers. A successful track record in attracting research funding would be advantageous. Excellent organisational and communications skills are essential, together with proven problem-solving skills and initiative.

Fixed-term: The funds for this post are available until 30 September 2019 in the first instance.

[Close 22 Apr 2018] Two Sr / Research Assocaite positions in Protein Design

Two positions are available in the laboratory of Professor Dek Woolfson, University of Bristol

For more information on the Woolfson group see: http://www.chm.bris.ac.uk/org/woolfson/index.html

For informal enquiries please contact: d.n.woolfson@bristol.ac.uk

Senior Research Associate / Research Associate in Protein Design for Biotechnology

http://www.jobs.ac.uk/job/BIT158/senior-research-associate-research-associate-in-protein-design-for-biotechnology/

A position for a postdoctoral research associate is available to work on a protein design in biotechnology project in the laboratory of Professor Dek Woolfson.  The group is internationally leading in the development of protein design for applications in chemical and synthetic biology.  The successful applicants will join a vibrant research team that combines bioinformatics and computational design, peptide and protein chemistry, biophysics and structural biology, and cell biology.  Expertise in peptide chemistry and biophysical methods would be a distinct advantage for this particular post, and applicants from these areas are particularly encouraged to apply.  However, we are keen to receive applications from ambitious and energetic individuals across the chemical and biochemical sciences or bioengineering with an interest in advancing protein design and its applications generally.

This post in protein design for biotechnology is for one year, and it is funded by a European Research Council Proof-of-Concept grant.  The project will explore the use of a-helical barrels recently discovered and developed in the Woolfson lab (Thomson et al. (2014) Science 346:485-488) in the area of biosensing. Researchers with a background in peptide chemistry, surface chemistry and/or fluorescence spectroscopy/microscopy are strongly encouraged to apply.  An active interest in driving the translation of this basic research into biotechnology applications of societal benefit would be an advantage.

Senior Research Associate / Research Associate in Protein Design

http://www.jobs.ac.uk/job/BIP002/senior-research-associate-research-associate-in-protein-design

A position for a postdoctoral research associate is available to work on protein design in the laboratory of Professor Dek Woolfson.  The group is internationally leading in the development of protein design for applications in chemical and synthetic biology.  The successful applicant will join a vibrant research team that combines bioinformatics and computational design, peptide and protein chemistry, biophysics and structural biology, and cell biology.  Expertise in computational biochemistry and/or structural biology would be a distinct advantage for this post, and applicants from these areas are particularly encouraged to apply.  However, we are keen to receive applications from ambitious and energetic individuals across the chemical and biochemical sciences or bioengineering with an interest in advancing protein design and its applications generally.

The post is available for an initial two-year period and is extendable to a further two years upon a successful start to the project.  This is funded by a grant from the Biotechnology and Biological Research Council of the UK.  The post-holder would be joined in year 2 by an expert in machine learning and virtual reality (VR) working in the laboratory of Dr David Glowacki (Chemistry, Bristol).  Together, these two post-doctoral research associates will develop VR methods to aid and advance the computational design of completely new proteins building on research programmes across the two labs (Thomson et al. (2014) Science 346:485-488; Wood et al. (2017) Bioinformatics 33:3043-3050; https://arxiv.org/pdf/1801.02884.pdf).  There will also be considerable opportunity to work with the international experimental and computational protein design and engineering communities.

Opportunity to join an exciting new start-up to develop insect tracking and quantification device via IoT

An exciting opportunity is available to work with a young up-and-coming start-up company.  As part of their research development, they are interested in creating an IoT demo device for insect tracking and quantification and could use some engineering help.

They are looking to make a device that can:

  1. Use vision tech to classify broad categories of insects
  2. Combine cloud-based hyper-localized data (weather conditions, time, etc.) with pollinator data. 
  3. Develop an IoT edge device
  4. Design a chemical release mechanism controlled electronically

The position is temporary to begin with, with a view to develop a permanent position in the future if the fit is right. The position would be based in London, but the company are open to applicants who aren't based in London, but are happy to travel on occasion.

ABOUT POM:

Insect pollinators provide a vital ecosystem service for crop pollination in wild plants, and over 75% of crops worldwide benefit from insect pollination through increased yields at harvest. The number of wild pollinators, especially bees is steadily declining. This documented decline poses a significant risk to the production of many crops and threatens food security.

POM encourages flies to be more efficient pollinators, in scenarios where bees are no longer as viable. Flies are already adept pollinators, being the main pollinators in urban environments, and in total, accounting for over 30% of all pollination.

POM provides horticultural growers with information on pollinators and environmental conditions and uses chemical volatiles to manage pollinating fly species, thereby increasing crop productivity, and ensuring sustainable food harvests for the future.

KEY RESPONSIBILITIES:

We are looking to find an experienced Engineer who is interested in working with a young and exciting start-up that has recently taken on investment to develop an insect tracking IoT device.

The individual should have experience with working on Raspberry Pi, Cloud computing and IoT data connectivity. The position will report weekly developments to the POM team in our London office, and reports to the Senior Engineer remotely throughout the week.

This position is a two month contract with the potential to continue with the company after
the achievement of key milestones. Project Salary: £2,300+ per month

Click here to download the job description.

Interested? Contact hello@flypollination.com

www.flypollination.com

[Closes 26 Apr 2018] Bioinformatician - Single Cell Analysis at Earlham Institute

The Core Bioinformatics Group at the Earlham Institute (EI, Norwich, UK) is looking for an enthusiastic and dedicated Bioinformatician to support developments in single cell genomics at the institute. Apply here: http://www.earlham.ac.uk/bioinformatician-single-cell-analysis

The role:

This is a collaborative project with the successful candidate joining the group of Dr. David Swarbreck and working closely with wet and dry lab scientists in the groups of Dr. Iain Macaulay and Dr. Wilfried Haerty. The post-holder will establish and implement pipelines and processes for the analysis of single genome, epigenome and transcriptome data from a wide variety of biological systems. Delivering single cell data analysis in conjunction with faculty groups, the genomic pipelines team and external collaborators.

[Closes 26 Apr 2018] Bioinformatician - Genomics Pipelines at Earlham Institute

This position is within the Core Bioinformatics group working in collaboration with Ksenia Krasileva (University of California, Berkeley). Apply here: http://www.earlham.ac.uk/bioinformatician-genomics-pipelines

The role:

This group member will be working with the latest wheat genomic data and building a toolbox for functional analyses. Specifically, the candidate will be involved in developing software tools to help understand how new variation in NLR immune receptors is generated, updating variant calling pipelines to examine natural and induced variation in complex wheat genomes and integrating this information to enable functional characterization of wheat genes. The candidate will work independently and with members of the Swarbreck (EI) and Krasileva (UC Berkeley) Groups to develop computational tools and pipelines to analyse large datasets and interpret them in a variety of biological contexts.

[Closes 19 Apr 2018] Genomics Pipelines Senior Research Assistant (Automation) at Earlham Institute

Applications are invited for Senior Research Assistant to join the Genomics Pipelines Group at the Earlham Institute. Apply at http://www.earlham.ac.uk/genomics-pipelines-senior-research-assistant-automation

The role:

The SRA will support the automation of high-throughput workflows for the Genomics Pipelines group and the DNA Foundry at the Earlham Institute. The SRA will play a key role in automating, troubleshooting and streamlining both current and future pipelines in a rapidly changing and technology-led environment. The SRA will also assist production teams with the preparation of next-generation sequencing libraries and the building and testing of engineered organisms as required by customers’ and collaborators’ projects.

The SRA will work closely with other laboratory staff in Genomics Pipelines and DNA Foundry to plan, execute and deliver scheduled high throughput and/or novel techniques. The SRA will transition complex, and cutting-edge laboratory processes onto EI’s installed base of liquid handling robotics platforms, as well as ensuring the smooth day-to-day running of laboratory automation, and deliver training to other RAs using automated protocols for deployment into production.

The SRA will ensure efficient, effective and safe operations of the automation they are responsible for. They will train Research Assistants on using automated protocols until they are handed over for production.

The SRA’s work will support Earlham’s strategic science programmes and the National Capability in Genomics and Single Cell Analysis, and DNA foundry.

[Closing March 6 - April 10] Several lectureship opportunities at Edinburgh University

Lecturer or Senior Lecturer in Synthetic Biology (vacancy ref: 042732)

We seek an excellent scientist and inspiring teacher who uses synthetic biology methods in research programmes such as genome engineering, biotechnology, metabolic engineering, genetic circuit design and engineering (both in vivo and cell free), bio-sensing, multi-cellularity and tissue engineering, regenerative medicine, novel vaccine development or addresses key questions in molecular or cell biology. The Edinburgh Genome Foundry’s facilities for automated DNA assembly can support large-scale synthetic biology and synthetic genomics research and we would be particularly enthusiastic about research programmes that took advantage of these capabilities.

Closing date – March 22nd

Contact – Prof Susan Rosser (Susan.Rosser@ed.ac.uk)

 

Lecturer in Biological Mass Spectrometry (vacancy ref: 042692)

We seek an excellent scientist and inspiring teacher who applies mass spectrometry (MS) in innovative ways to tackle major challenges in biology. We are looking for researcher who is addressing key questions in areas such as cell biology, structural biology, immunology, microbiology, biotechnology or systems biology, by exploiting the unique sensitivity, accuracy and resolving power of modern and emerging MS techniques.

Closing date – April 5th 2018

Contact – Prof Paul Barlow (Paul.Barlow@ed.ac.uk)

 

Lecturer in Computational Biology (vacancy ref: 042673)

We seek an excellent scientist and inspiring teacher who uses and develops computational and modelling techniques to address key questions in biology. We welcome applications from researchers in all areas of computational biology, and we are particularly looking for those working in the following fields: metabolism, such as the application of flux balance analysis and the analysis and interpretation of data from metabolomics and fluxomics experiments; multi-scale modelling of biological systems, including formal modelling techniques and stochastic modelling; and data science approaches to biological research, including the analysis of data from next generation sequencing.

Closing Date - 13th March 2018

Contact – Prof Peter Swain or Prof Guido Sanguinetti (Peter.swain@ed.ac.uk or gsanguin@inf.ed.ac.uk)

 

Lecturer in Stem cell Biology (vacancy ref 042667)

We seek an excellent scientist and inspiring teacher who addresses key questions in stem cell biology or developmental biology that are directly relevant to stem cell or regenerative biology. We particularly encourage applications from candidates who employ single cell or synthetic approaches

Closing Date – April 10th

Contact – Prof Donal O’Carroll Donal.ocarroll@ed.ac.uk

 

Lecturer in Molecular Crop Science (vacancy ref: 042668)

We seek a creative scientist and inspiring teacher who applies molecular approaches to address important fundamental and translational questions in plant biology that are relevant to crop improvement and food security.

Closing Date – March 15th

Contact – Prof Andrew Hudson (Andrew.hudson@ed.ac.uk)

 

Lectureship in Biochemistry (vacancy ref 042671)

This four-year lectureship position offers an outstanding opportunity to develop an independent teaching and research programme. We seek an excellent scientist and inspiring teacher to join a group of successful scientists with teaching and research interests across RNA and cell biology, synthetic biology, systems biology, biochemistry and biotechnology. At Edinburgh we emphasise cross-disciplinary thinking in a collaborative and well-supported environment. You will benefit from this to build your own portfolio of research and scholarship. You will make an important contribution to the development and delivery of high-quality and inspirational undergraduate and postgraduate teaching, including the opportunity to develop eLearning and on-line education initiatives. You will have a PhD in a relevant area of biology or chemistry and a published record of research, along with a successful track record of developing innovative and engaging teaching.

Closing Date – March 6

Contact – Prof Paul Barlow (paul.barlow@ed.ac.uk)

 

For all roles, please apply online at vacancies.ed.ac.uk

[Closes 22 Mar 2018] Vacancy for Lecturer or Senior Lecturer in Synthetic Biology at University of Edinburgh

Vacancy: Lecturer or Senior Lecturer in Synthetic Biology

We seek an excellent scientist and inspiring teacher who uses synthetic biology methods in research programmes such as genome engineering, biotechnology, metabolic engineering, genetic circuit design and engineering (both in vivo and cell free), bio-sensing, multi-cellularity and tissue engineering, regenerative medicine, novel vaccine development or addresses key questions in molecular or cell biology. The Edinburgh Genome Foundry’s facilities for automated DNA assembly can support large-scale synthetic biology and synthetic genomics research and we would be particularly enthusiastic about research programmes that took advantage of these capabilities.

You will have the ability, enthusiasm and breadth of vision required to be a future leader in this rapidly moving field. You will pursue an independent research programme, working collaboratively and leading a team. You must have an established track record of relevant publications and the potential to win future investment in research, and will be expected to engage with both commercial and public research users and funders. You will be enthusiastic about teaching and student-centred learning for both undergraduate and postgraduate students.

The University of Edinburgh is a vibrant, research-driven community offering opportunities to work with internationally leading academics whose visions are shaping tomorrow’s world. The School of Biological Sciences is one of the UK’s largest and most highly rated life sciences departments, providing an innovative environment for research and teaching with a strong emphasis on interdisciplinary research. SynthSys, the Centre for Synthetic and Systems Biology, is one of the largest groupings of systems and synthetic biologists in the UK with expertise ranging from microbes to mammalian cells working on applications in biotechnology and medicine as well as contributing to foundational and fundamental research. SynthSys is highly multidisciplinary with members from the schools of engineering, informatics, chemistry, physics, social sciences, medicine as well as biological sciences. You will join a team of group leaders working at the interface between molecular cell biology and quantitative science, with strong links in biotechnology.

Informal enquiries: Prof Susan Rosser susan.rosser@ed.ac.uk

This posts are full time and open ended.

Salary: UE08 £39,992 - £47,722 per annum / UE09: £50,618 - £56,950 per annum

Closing Date: Thursday 22nd March 2018 at 5pm (GMT)

To apply: www.vacancies.ed.ac.uk search for #042732

[Closes 12 Mar 2018] OpenPlant and SynBio SRI seek new Coordinator - apply now!

The University of Cambridge is seeking a Co-ordinator for two Synthetic Biology research initiatives. The role-holder would work 50% to support the OpenPlant Synthetic Biology Research Centre and 50% with the Synthetic Biology Strategic Research Initiative (SynBio SRI).

We are seeking a Co-ordinator for two Synthetic Biology research initiatives at the University of Cambridge. The role-holder would work 50% to support the OpenPlant Synthetic Biology Research Centre and 50% with the Synthetic Biology Strategic Research Initiative (SynBio SRI). The purpose of the role is to help develop and implement a strategy that will enable both initiatives to become known leaders in the field and sustainable in the longer term.

OpenPlant (http://openplant.org) is a consortium funded by BBSRC and EPSRC comprising 20 labs spanning the University of Cambridge, John Innes Centre and the Earlham Institute (Norwich). The work of the Research Centre is intended to promote novel research on tools and applied traits for plant synthetic biology, open sharing of foundational technologies, and responsible innovation. The role-holder will work with the OpenPlant Directors and Management Group, including the OpenPlant Project Manager based in Norwich, to co-ordinate a variety of activities within the Research Centre.

The SynBio SRI (http://synbio.cam.ac.uk) aims to catalyse interdisciplinary exchange between engineering, physics, biology and social sciences to advance Synthetic Biology at the University of Cambridge. The role-holder will work with the SRI Co-Chairs and Steering Committee to develop, plan and deliver the SRI's vision and strategy. They will facilitate efforts to promote development of open technologies, build shared resources, and provide a hub for networking and discussion.

Responsibilities will also include co-ordinating seed funding competitions such as the Biomaker Challenge and OpenPlant Fund; organising formal and informal scientific meetings and forums; developing and managing relationships with stakeholders within and external to the University; seeking small and large-scale funding for future activities. The role-holder is additionally responsible for ensuring that synthetic biology activities in Cambridge are actively communicated and promoted, and is supported by the part-time SynBio SRI Events and Communication Co-ordinator.

The successful candidate will have a PhD in a relevant field and knowledge of Synthetic Biology research, policy and practice. They will have the ability to foster relationships with and between academics at all levels in an interdisciplinary context, and build partnerships with companies, funders and policy makers. A successful track record in attracting research funding would be advantageous. Excellent organisational and communications skills are essential, together with proven problem-solving skills and initiative.

 For more information and to apply >>

[Closes 20 Feb 2018] Synthetic Biology Postdoc at Earlham Institute

OpenPlant PI Dr Nicola Patron is looking for a Postdoctoral Research Scientist to work on a European Research Area (ERA) CoBioTech collaborative project based in the Patron Lab at the Earlham Institute. The project will use will use synthetic biology, comparative transcriptomics, metabolic engineering and genome editing/engineering techniques to develop plants and fungi as low-cost, sustainable production platforms for biosynthesis of insect pheromones..

Apply now >>
Closing date 20th February 2018

SUSPHIRE-text.png

[Closes 2 Jan 2018] Postdoc in Synthetic Biology at Newcastle University

Newcastle University are seeking a highly motivated experimental synthetic biology researcher to join Dr Angel Goñi-Moreno’s team at the Interdisciplinary Computing and Complex BioSystems (ICOS) group and the Centre for Synthetic Biology and the Bioeconomy of Newcastle University. You will work on the project “SynBio3D: Establishing the engineering fundamentals of three-dimensional synthetic biology”.

This project seeks to integrate spatial constraints such as distances and molecular crowding into the design and construction of gene regulatory circuits. Each gene sequence and each protein may need a specific physical address in the spatial frame of a cell for optimal performance (see http://pubs.acs.org/doi/abs/10.1021/acssynbio.6b00397 ), a fundamental question to be addressed by the project. This will bring spatial resolution to synthetic biology. Single molecules and DNA components will be tracked inside living cells. This project offers a fantastic playground for a researcher in synthetic biology to conduct highly novel research.


You will have a PhD awarded, or be close to obtaining one, with a significant molecular biology, genetic engineering or related component. You will have skills in the construction and validation of synthetic genetic circuits in bacterial cells. You will have knowledge in genome editing techniques. You will have experience in using fluorescence microscopy and, ideally, the visualization of gene expression constituents in individual cells. Experience in super-resolution microscopy is not essential, but will be positively considered. You will possess strong interests in the application of single-molecule tracking to synthetic biology problems.

You will need to be able to work independently as well as part of a team. Good communication skills are essential – our team includes computer scientists, engineers, biochemists, physicists and molecular biologists. Working under the supervision of senior colleagues, you will develop and initiate new collaborations both internally and externally. You will need to write up research results as well as to present our developments in national and international conferences and meetings. You will contribute to identify potential areas of research within the project and develop leadership skills.

The post is available fixed term for 24 months with start date as soon as possible.
Interviews will take place in January 2018, exact date to be confirmed upon invitation.

More information >>

[Deadline 15 Dec 2017] Faculty Openings at Northwestern Center for Synthetic Biology

The Feinberg School of Medicine at Northwestern University invites applications for a tenure-track position at the rank of Assistant Professor in the Center for Synthetic Biology

Applicants should have a PhD and postdoctoral experience in a field related to synthetic biology and should have research plans that apply synthetic biological approaches to biomedical goals. Ideal candidates should also demonstrate strong communication and leadership skills, as well as an ability to contribute actively to a rapidly growing Center.

Northwestern University has recently started the Center for Synthetic Biology as a university-wide initiative to formalize and grow Synthetic Biology as a research theme. Northwestern University offers superb start-up packages with a collegial and collaborative scientific environment that is rich with core facilities, robust cross- disciplinary graduate training programs, and diverse expertise.

Candidates should have a Ph.D. and/or a M.D. degree and postdoctoral experience. Salary is commensurate with experience and accomplishment.

Deadline: review of received applications will start December 15, 2017, and will continue until the position is filled. 

More information  >>

Apply >>

 

[Closes 5 Jan 2018] Two post-doctoral fellowships in plant synthetic biology at Colorado State University

The Antunes and Medford Research groups at Colorado State University are looking for two (2) post-doctoral fellows to work on a new plant synthetic biology project to produce useful, living biomaterials

 A Ph.D. in plant molecular biology, cell biology, synthetic biology or a related field is required. Ideal applicants will have experience in molecular biology, plant cell biology and gene cloning. Experience in synthetic biology, design of synthetic genes and gene circuits, and basic mathematical modeling is desired; however, strong candidates without experience in one of these areas may be considered. Experience in moss culture and transformation is valued. Experience with transgenic plants is helpful but not essential.

Well-developed skills in written and verbal communication are desirable. The incumbents are expected to interact with other post-docs, graduate students, lab technicians and undergraduate students in a positive and professional manner.

Duties include applying a variety of molecular biology techniques, gene expression studies, synthetic gene construction, production and analysis of transgenic plants, planning experimental approaches based on research literature, and interpreting results. The successful individuals will be self-motivated and capable of independent thought and research.

More information and to apply >>

Deadline is January 05, 2018.

[Closes 31 Dec 2017] Applications for the 2018 EUSynBioS Steering Committee are now open !

EUSynBioS is a community for students and postdocs in European synthetic biology. Applications to join their 2018 Steering Committee are now open until 31 December 2017, where you can help facilitate horizontal connections across the synthetic biology community and convene joint events with fellow communities around the globe.

Christian Boehm, who recently completed his PhD at the University of Cambridge is the current EUSynBioS Chair and sends this message:

"Dear EUSynBioS community,

As you know, this initiative is run entirely by dedicated students and postdocs keen to make a difference in European synthetic biology. Over the previous year, we have had a fantastic group of people on the Steering Committee: they have amplified our social media presence, represented our voice in the UN Convention on Biological Diversity's discussions on synthetic biology, organised the EUSynBioS Social in Manchester and of course our EUSynBioS Symposium at CNB-CSIC Madrid.
The fourth year of EUSynBioS shall facilitate horizontal connections across the community, further strengthen our interface to industry, and bring about more joint events with fellow communities around the globe.

Do these challenges sound appealing to you ?
Do you have an idea which would really make a difference to the community ?
Do you have what it takes to be a leader in European synthetic biology ?

Then be a part of the 2018 EUSynBioS Steering Committee!
Applications are now open until 31. December 2017. We will be in touch with you soon thereafter, and aim to announce our 2018 Steering Committee in early January."

More information and to apply >>

[Closes Dec 2017] Eligo Bioscience seeking synthetic biologist and related positions

Eligo Bioscience are recruiting a new cohort of amazing scientists and executives to work with us on one of the most exciting synthetic biology-based drug-development platforms. To build the next generation of targeted drugs, they are looking for the most talented microbiologists, genome architects, bioengineers, and DNA hackers to join one of their R&D teams

Eligo Bioscience are recruiting a new cohort of amazing scientists and executives to work with us on one of the most exciting synthetic biology-based drug-development platforms. To build the next generation of targeted drugs, they are looking for the most talented microbiologists, genome architects, bioengineers, and DNA hackers
to join one of their R&D teams

 

Synthetic Biologist / Geneticist

To be able to translate our research to the clinic, we need to genetically engineer our producer strains to enable the packaging of synthetic circuits into our eligobiotics, and also to optimize the genetic circuits themselves to perform well in in-vivo models.

We are looking for excellent molecular biologists / synthetic biologists excited to tackle the ambitious challenges of diving into phage genetics and engineering bacterial strains.

The ideal candidate is passionate about genetic engineering. You’ll work hand-in-hand with Eligo microbiologists, phage biologists, and animal model scientists to optimize the engineering and validation of eligobiotics


Microbiologist

Eligo is building a platform technology to produce an arsenal of eligobiotics to target a wide range of bacterial species. With such a capability, Eligo is poised to lead the new generation of precision microbiome engineering companies. To build our library of delivery vectors based on phage capsids, we need to turn wild-type bacterial strains into engineered producer strains.

We are looking for excellent microbiologists excited to tackle the challenge of engineering and optimizing bacterial strains (aerobic/anaerobic, gram pos/gram neg, etc) to enable the production of species-specific eligobiotics. The ideal candidate is passionate about microbiology and molecular biology.

You’ll work hand-in-hand with Eligo phage biologists, synthetic biologists, and animal models scientists to optimize the engineering and validation of eligobiotics candidates for clinical trials.candidates for clinical trials.


Phage Biologist

To build our library of delivery vectors based on phage capsids, we need not only to discover and characterize a large number of phages with unique capabilities, but also validate their in-vivo activity.

We are looking for phage experts excited to tackle the challenge of both screening environmental samples and bacterial collections to discover unknown phages and characterizing them once isolated. Our whole process is now highly automatized thanks to our robotic pipeline.

The ideal candidate is passionate about phage biology and phage therapy. You’ll work hand-in-hand with Eligo microbiologists, genetic engineers, and animal model scientists to optimize the engineering and validation of eligobiotics candidates for clinical trials.

[Closes 30 Nov 2017] PhD Internship available: BrisSynBio Innovations Officer

BrisSynBio are looking for an enthusiastic individual to support some of BrisSynBio's innovation activities in 2018. They will develop, organise and participate in the BrisSynBio 4-Day More Business Acumen (MBA) course

This hands-on programme provides entrepreneurship and business training to synthetic biologists and culminates in a dragons’ den pitching event with venture capitalists and £10,000 of prizes. They will also support the broader activities of the innovation programme including industrial networking and translational funding as required.

The post will be located in the Life Sciences Building on the University of Bristol campus, but may also include travel within Bristol and the UK. Applicants should have good organisational, communication, and interpersonal skills and be available to start in February 2018.

Deadline: 30 November 2017 

https://pipsadverts.wordpress.com/2017/10/20/bristol-centre-for-synthetic-biology-brissynbio/

 

[Closes 27 Nov 2017] PhD on plant gene regulation

PhD available with Dr Nicola Patron of the Earlham Institute on design principles for synthetic gene regulation - understanding how cis-regulatory functions are encoded in plant DNA.

Plants are emerging as commercially-relevant production systems for high-value natural products. This requires suites of non-homologous, characterised regulatory elements for applications such as balancing components within a responsive circuit and preventing the build-up of toxic intermediates along a biosynthesis pathway. Plant regulatory sequences are comprised of complex arrangements of protein binding motifs and cis-regulatory elements. Both the primary DNA sequence and secondary DNA structure contribute to regulating gene-expression by recruiting proteins and dictating nucleosome architecture. This project will apply an original synthetic-biology approach to study the relationship between sequence and function utilising comparative genomic approaches to inform the design of synthetic regulatory sequences. This will enable us to understand how cis-regulatory function is encoded in specific DNA sequences. The project will focus on the identification and characterisation of cis-regulatory elements conserved across plants to inform the design of minimal synthetic elements that function across species. Comparative analysis of genome sequences will be used to inform iterative 'design-build-test-learn' cycles in which the function of libraries of designed, synthetic sequences will be analysed. The student will be trained in bioinformatics and comparative genomics analyses, synthetic biology approaches and low and high-throughput plant molecular biology and biotechnology techniques.

More information and application >>

[Closes 12 Jan 2018] Synthetic Biology Centre for Doctoral Training 2018 Cohort is now open for applications

The Synthetic Biology Centre for Doctoral Training (CDT) is a collaboration between the Universities of Bristol, Oxford and Warwick. It offers a four-year training programme leading to a PhD. The programme is designed for students with both physical and life sciences backgrounds.

More information and to apply >>

The first two terms are in Oxford, taught by staff from all three institutions, and devoted to acquiring the necessary theoretical and technical skills, through a combination of intensive lecture courses, practicals, seminars, project work and training in research and communication skills.

Over the third term and summer period at the end of the first year, students will undertake two extended projects, each lasting about 10 weeks. These are similar in scope to a master's-level project and serve as both advanced training and to help students  choose their research topic for the final three years of the course.

After completing these projects, students will undertake substantive PhD research projects in synthetic biology in their home participating university.

The Synthetic Biology CDT will produce internationally excellent researchers with key skills desired by prospective employers in the nascent field of synthetic biology.

[Closes 27 Nov 2017] PhD on plant gene regulation

PhD available with OpenPlant PI Dr Nicola Patron of the Earlham Institute on design principles for synthetic gene regulation - understanding how cis-regulatory functions are encoded in plant DNA.

Plants are emerging as commercially-relevant production systems for high-value natural products. This requires suites of non-homologous, characterised regulatory elements for applications such as balancing components within a responsive circuit and preventing the build-up of toxic intermediates along a biosynthesis pathway. Plant regulatory sequences are comprised of complex arrangements of protein binding motifs and cis-regulatory elements. Both the primary DNA sequence and secondary DNA structure contribute to regulating gene-expression by recruiting proteins and dictating nucleosome architecture. This project will apply an original synthetic-biology approach to study the relationship between sequence and function utilising comparative genomic approaches to inform the design of synthetic regulatory sequences. This will enable us to understand how cis-regulatory function is encoded in specific DNA sequences. The project will focus on the identification and characterisation of cis-regulatory elements conserved across plants to inform the design of minimal synthetic elements that function across species. Comparative analysis of genome sequences will be used to inform iterative 'design-build-test-learn' cycles in which the function of libraries of designed, synthetic sequences will be analysed. The student will be trained in bioinformatics and comparative genomics analyses, synthetic biology approaches and low and high-throughput plant molecular biology and biotechnology techniques.

More information and application >>

 

[Closes 31 Oct 2017] University of Cambridge Lectureship in Synthetic Biology

Applications are invited for a University Lectureship in Synthetic Biology at the University of Cambridge. This is a tenure-track position based in the Department of Engineering and is supported by the School of Biological Sciences (SBS). We particularly encourage applicants who complement current research within Engineering, SBS and across the University, and who are motivated to explore interdisciplinary collaborations.

The successful candidate will have an established DNA-based experimental research program in a topic including, but not limited to:

  • Design and engineering of synthetic genetic circuits (both cellular and cell-free)
  • Genome engineering
  • Biosensing and biological signal processing
  • Spatio-temporal gene regulation
  • Engineering of multicellular interactions and tissue structure/function

In addition, research may combine theoretical and numerical approaches with experiments. The successful candidate will have, or be expected to develop, a record of world-class research commensurate with the international reputation and top-rank research rating of the Department.

The candidate will be expected to contribute exciting and innovative teaching material to our rapidly growing bioengineering courses in the Engineering curriculum, with teaching and administration accounting for approximately 40% of the role. Teaching responsibilities will include contributing to undergraduate courses, supervising undergraduate projects, examining and supervising postgraduate students.

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